biOasis Announces the Issuance of a Key US Patent for the Delivery Through the Blood-Brain Barrier of Therapeutic Antibodies – Inclusive of Trastuzumab – to Treat Her2/neu Brain Metastases

biOasis’ Transcend Platform has shown great utility in pre-clinical animal models to deliver therapeutic compounds into the brain at sufficient levels to reach a therapeutic effect. Without the Transcend delivery vehicle these compounds would otherwise be excluded from the brain due to the presence of the protective blood-brain barrier. The issuance of this patent indicates that compounds, such as in this case Trastuzumab can be, with the help of Transcend, protected under the issuance of a new patent, including for a new therapeutic indication – brain metastases. Trastuzumab coupled to the transport vector Transcend thus offers a potential treatment for this dreadful cancer.

Vancouver, BC–(Business Wire)– biOasis Technologies, Inc. (OTCQB:BIOAF; TSX.V:BTI), a pioneering biopharmaceutical company focused on overcoming the limitations of therapeutic drug delivery across the blood-brain barrier (BBB), announces the full and final issuance of a US patent covering the delivery by Transcend of cancer therapeutics to the brain to treat an aggressive form of brain cancer – Her2+/nue brain metastases.

Her2+ brain cancer is a form of an aggressive breast cancer that travels (metastasizes) to the brain at a high frequency. In 2012 it was noted that upwards of 20% of Her2+ breast cancer patients exhibited brain metastases. Today, the incidence has been reported to be as high as 40%*. Arguably this is due to the tremendous job achieved by the primary drug used to treat this form of cancer, Trastuzumab (brand name Herceptin©). Since its introduction as a therapeutic treatment, Trastuzamab has increased survival significantly, but as a result there is a higher incidence of Her2/neu brain metastases. This drug alone does not readily cross the blood-brain barrier and, as such, the treatment of metastatic brain cancer presents a significant challenge to physicians. biOasis, in collaboration with a number of independent third parties, including Texas Tech University, the National Research Council of Canada and the BC Cancer Research Centre, has shown some highly promising results using biOasis’ combination of Trastuzumab with its Transcend delivery platform to deliver the therapeutic to the brain.

“We filed this patent in 2012 when we first obtained our positive results with the Trastuzamab-Transcend combination and to have the patent fully granted by 2015 is a wonderful example of the tremendous opportunity for the Transcend family as a whole” said Rob Hutchison CEO, “ and it shows that the marriage of our Transcend platform with an on or off patent therapeutic can obtain patent protection for our shareholders. But much more importantly, this may one day offer a treatment for those patients who may see brain involvement of this dreaded disease even after beating the primary site location. This patent greatly enhances biOasis’ intellectual property position and along with collaborators, such as the Harvard research team at Brigham & Women’s Hospital, enables us to advance in earnest our MTfp-TZM program with the ultimate goal to have a therapeutic protocol for Her2/neu brain metastases.”


About biOasis

biOasis Technologies Inc. is a biopharmaceutical company headquartered in Richmond, Canada focused on overcoming the limitations of therapeutic drug delivery across the BBB. The company is developing and commercializing a proprietary brain delivery technology to address unmet medical needs in the treatment of central nervous system disorders. biOasis trades on the OTCQB under the symbol “BIOAF” and on the TSX Venture Exchange under the symbol “BTI”. For more information about the company please visit

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On Behalf of the Board of Directors

Rob Hutchison, Chairman & CEO

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