biOasis Receives Final Results from BC Cancer Research Centre Herceptin® Studies

Vancouver, BC–(Business Wire)– biOasis Technologies Inc. (TSX.V:BTI) announced today the results from two additional studies conducted by the BC Cancer Research Centre (BCCRC). The additional studies confirmed and extended earlier data showing that BT2111, a conjugate made up of biOasis Transcend vector and trastuzumab (trade name Herceptin®), a humanized monoclonal antibody used clinically in the treatment of HER2+ breast cancer, shows a markedly increased ability to kill a HER2+ breast cancer cell line when compared to trastuzumab alone.

“The initial pilot BT2111 study results from BCCRC were very compelling and this prompted us to conduct additional work to confirm those initial findings,” said Rob Hutchison, CEO. “As further support we also undertook preliminary confocal imaging at the James Hogg Research Centre of brain sections taken from animals that were administered BT2111 intravenously. This final BCCRC data of BT2111 activity against breast cancer cells along with the 3D confocal images which confirmed the presence of BT2111 in brain cells, gives us additional confidence in moving the BT2111 program forward to treat breast cancer metastases in the brain.”

Herceptin® is the registered trade mark of Genentech, Inc.


BT2111 is a conjugate between biOasis’ Transcend brain delivery vector and trastuzumab (trade name Herceptin®), a humanized monoclonal antibody used clinically in the treatment of HER2+ breast cancer. Because of its ability to cross the blood-brain barrier and enter the tissues of the brain biOasis is studying BT2111 as a possible approach to treating HER2+ metastatic breast cancer in the brain. It is reported that up to 30% of HER2+ breast cancer patients end up developing brain metastasis.


biOasis Technologies Inc. is a biopharmaceutical company engaged in the development and commercialization of products for the diagnosis and treatment of neurological diseases and disorders. Its products and technologies are intended for use within the healthcare and life science research markets. biOasis is developing a proprietary carrier for the transport of therapeutic and imaging agents across the blood-brain barrier – Transcend. Current initiatives within the Transcend program include production of materials for preclinical studies and conjugation to a range of small molecule and biologic therapeutics. To address the unmet clinical need to transport drugs across the blood brain barrier biOasis intends to license Transcend to multiple corporate partners.

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On Behalf of the Board of Directors
Robin Hutchison
Chairman & CEO