biOasis’s Update on the BT2111-Herceptin® Program

Vancouver, British Columbia–(Business Wire)– biOasis Technologies Inc. (TSX:V.BTI) announced today an update on the advancement of its anti-cancer product candidate BT2111. BT2111 is a brain- penetrating conjugate of trastuzumab (Herceptin®) and our Transcend vector designed to treat brain metatastsis of HER2+ breast cancer. Based on the exceptional data announced on February 7th of this year, which show both a remarkable reduction on brain tumors as well as tumor size, the company along with its expert industry advisors has now developed the road map to take this program to the next stage of preclinical development.

“Through late 2011 and through 2012 the BT2111 program has delivered tremendous results for biOasis,” says Rob Hutchison, CEO. “The news out of Texas Technical University announced on February 7th exceeded our expectations going into the program. Based on these animal efficacy studies we were then in a position to plan the balance of the pre-clinical pathway. There are a number of key studies that we will undertake as soon as possible to further evaluate and characterize BT2111 in order to position the program for out licensing to a pharmaceutical partner or for further internal pre-clinical development. This work will include additional efficacy, pharmacokinetic and safety sudies. The next efficacy study is planned and can commence shortly and we expect to see results from this work by mid to late summer.”

ABOUT BT2111 – BT2111 is a conjugate between biOasis’ Transcend brain delivery vector and trastuzumab (trade name of Herceptin®), a humanized monoclonal antibody used clinically in the treatment of HER2+ breast cancer. It is reported that up to 30% of HER2+ breast cancer patients develop brain metastasis for which therapeutic options are limited. Because of its ability to cross the blood-brain barrier, biOasis is researching the potential of BT2111 for treatment of HER2+ metastatic breast cancer in the brain.

Herceptin® is a registered trademark of Roche/Genentech.


biOasis Technologies Inc. is a biopharmaceutical company headquartered in Vancouver, Canada. Based on Transcend, biOasis proprietary brain delivery platform, the Company is focused on creating new drugs that can cross the blood-brain barrier to address unmet medical needs in the treatment of brain diseases such as neurodegeneration, metastatic cancer and metabolic diseases. biOasis trades on the TSX Venture Exchange under the symbol “BTI”. For more information about the Company please visit

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biOasis Technologies Inc.
On Behalf of the Board of Directors
Robin Hutchison, 778-383-3280
Chairman & CEO
[email protected]