Discovery of a highly conserved peptide in the iron transporter melanotransferrin that traverses an intact blood brain barrier and localizes in neural cells.
Chaahat S.B. Singh, Brett A. Eyford, Thomas Abraham, Lonna Munro, Kyung Bok Choi, Mark Okon, Timothy Z. Vitalis, Reinhard Gabathuler, Chieh-Ju Lu, Cheryl G. Pfeifer, Mei Mei Tian, Wilfred A. Jefferies
Front Neurosci 2021 Jun 2, 15:596976
A nanomule peptide carrier delivers siRNA across the intact blood-brain barrier to attenuate ischemic stroke.
Brett A. Eyford, Chaahat S.B. Singh, Thomas Abraham, Lonna Munro, Kyung Bok Choi, Tracy Hill, Rhonda Hildebrandt, Mark Okon, Ian Welch, Timothy Z. Vitalis, Reinhard Gabathuler, Jacob A. Gordon, Hans Adomat, Emma S.T. Guns, Chieh-Ju Lu, Cheryl G. Pfeifer, Mei Mei Tian, Wilfred A. Jefferies
Front Mol BioSci 2021 Mar 26, 8:611367
The use of peptide and protein vectors to cross the blood-brain barrier for the delivery of therapeutic concentration of biologics.
Mei Mei Tian, Reinhard Gabathuler.
Morales J.O., Gaillard P.J. (eds) Nanomedicines for brain drug delivery. Neuromethods, vol 157. Humana, New York, NY.
A peptide derived from the protein melanotransferrin is able to cross the blood-brain barrier and to deliver a payload to therapeutic concentrations in the central nervous system.
Thom George, Tian Mei-Mei, Hatcher Jon, Rodrigo Natalia, Burrell Matthew, Gurrell Ian, Vitalis Timothy Z., Abraham Thomas, Webster Carl I., Gabathuler Reinhard
J. Cereb. Blood Flow Metab. 2019 39 (10), 2074-2088.
Anti-cancer antibody trastuzumab- melanotransferrin conjugate (BT2111) for the treatment of metastatic HER2+ breast cancer tumors in the brain: an in-vivo study.
Nounou, Mohamed I., Adkins Chris E., Rubinchik E., Terrell-Hall T. B., Afroz Mohamed, Vitalis Timothy Z., Gabathuler Reinhard, Tian Mei M., Lockman Paul R.
Pharm Res. 2016 Dec;33(12):2930-2942